Most patients with advanced prostate cancer are placed on some form of hormone treatment as the primary therapy for their prostate cancer. Hormone refractory prostate cancer (also known as 'HRC') refers to patients whose cancer is progressing after or while on hormone therapy. HRC includes: * Men who have had radical prostatectomy or radiation or implants and because of a high likelihood of recurrence of cancer are placed on hormone treatments and then develop a rising PSA without other evidence of cancer. * Men without symptoms on hormone therapy for metastatic cancer and have a rising PSA or change in bone scan or other cancer diagnostic test. * Men with increasing symptoms of cancer while on hormone therapy regardless of PSA or other blood tests. Initial Hormone Therapy For Prostate Cancer-Review Male hormones are usually referred to as 'androgens'. The most important and one of the most powerful androgens is testosterone. Almost all of the male's testosterone is ma